M.Phil., Genomic Science, Central university of Kerala
M.Sc., Biotechnology, Cochin University of Science and Technology
The domestic cattle, Bos taurus is one of the economically important livestock species in terms of milk, meat and agricultural purposes. My Ph.D research focus to establish nucleosome profile for the domestic cattle. The nucleosomes play two major roles in epigenetic regulation of gene expression, first it restricts the DNA accessibility to cellular machinery through specific positioning of nucleosome core particles and second it controls the transcriptional activities through covalent modifications of the tails of four core histone types. My aim is to determine the epigenetic mechanisms influencing the economically important traits in cattle. A high resolution nucleosomal map of cattle may provide deep insight into the epigenetic changes in the genome and in turn their effects on the phenotypic traits.
- Nagarajan M, Nimisha K and Kumar S. 2015. Mitochondrial DNA variability of domestic river buffalo (Bubalus bubalis) populations: Genetic evidence for domestication of river buffalo in Indian subcontinent. Genome Biology and Evolution.7 (5):1252–1259.
- Jikku Jose. K. Nimisha, M.A. Anu and Padma Nambisan. 2012. Evaluation of Somaclonal Variation in Callus Cultures of Jatropha curcas Maintained on Different Hormonal Combinations Using RAPD Markers. World Journal of Agricultural Sciences. 8 (6): 616-623.
- Jose J, Anu M A, Nimisha K and Nambisan P. 2011. Mitotic index in callus induced from leaf explants of Jatropha curcas. Journal of Cytology and Genetics.12 (2):43-49.
M.Sc., Genomic Science, Central University of Kerala (2013)
B.Sc., Microbiology, Kannur University (2011)
KSCSTE Research Fellowship (2014)
As a part of my M.Sc course, I carried out a study on “MHC gene polymorphisms in Indian Major Carps” under the mentorship of Dr. M Nagarajan. Later I joined as a Junior Research Fellow in a DST project entitled “Genetic diversity and origin of Indian domestic ducks”. Diseases were always a prime area of research in the field of biology. The modern molecular research is focusing on the genetic basis of diseases and other physiological process. In a population, individuals vary between their resistances to a particular disease. Many factors contribute to it and specifically one’s genetic constitution is an important factor. I explore the role of MHC gene polymorphisms in disease resistance in duck for my PhD.
Kameshpandian P, Thomas S & Nagarajan M. (2016) Genetic diversity and relationship of Indian Muscovy duck populations. Mitochondrial DNA Part A. DOI: 10.1080/24701394.2016.1261851
M.Phil., Biotechnology, (2014), Periyar University, Salem, Tamil Nadu
M.Sc., Biotechnology, (2013), AVS College of Arts and Science, Salem, Tamil Nadu
In the field of conservation genetics, much importance for protecting the wild life and domestic animal species and their habitats. In India, the genetic diversity of domestic sheep breeds is declining and results in breed dilution due to cross- breeding, inter-crossing of sheep germplasm and modern agricultural practices. For my Ph.D, I have focused to understand the genetic variability and diversity exist among different Indian sheep breeds using mtDNA markers.
Vandana R Prabhu
M.Sc., Genomic Science, Central University of Kerala
B.Sc., Zoology, Govt. College, Kasaragod, Kerala
I am presently working as a JRF in a research project entitled “Genetic diversity and origin of Indian domestic ducks”. Some of the fishes are capable of changing their sex during the course of sexual reproductive cycle. I am interested in finding out the changes in gene expression during sex reversal as well as eager to know whether environment has any influence on such enthralling trait.
Nagarajan M and Vandana R. Prabhu (2016). Genome-Wide Mapping of Nucleosome Position and Histone Code Polymorphisms in Yeast In: Big Data Analytics in Genomics, (eds. K.-C. Wong), Springer International Publishing, Switzerland.